Abstract
Dibenzenesulphonyl diethyl amine has been prepared and used as a starting material to be introduced as an alkylating agent. Reaction of dibenzenesulphonyl diethyl amine with indole in the presence of sodium and absolute ethanol gave seven unexpected products, five of which were separated by flash chromatography. The structure of product 5 was established on the basis of elemental analysis and spectral data [IR, H-1-NMR, C-13-NMR, distortionless enhancement by polarization transfer (DEPT), H-1-H-1 correlation spectroscopy (COSY) NMR, H-1/C-13 heteronuclear multiple quantum coherence (HMQC) NMR and mass spectra (CI/Ms and EI/Ms)]. The antibacterial activity of compound 5 is very compatible with ampicillin.
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