Sign in
Back
Synthesis and biological evaluation of benzyl styrylsulfonyl derivatives as potent anticancer mitotic inhibitors
Journal article   Peer reviewed

Synthesis and biological evaluation of benzyl styrylsulfonyl derivatives as potent anticancer mitotic inhibitors

Osama Chahrour, Ashraf Abdalla, Frankie Lam, Carol Midgley and Shudong Wang
Bioorganic & medicinal chemistry letters, Vol.21(10), pp.3066-3069
15/05/2011
DOI: https://doi.org/10.1016/j.bmcl.2011.03.041
PMID: 21463944

Abstract

Anticancer therapy Mitotic inhibitor Polo-like kinase Serine/threonine kinase
We herein report the synthesis, biological activity and structure activity relationship of derivatives of benzylstyrylsulfone, benzylstyrylsulfine and benzylsulfonyl- N-phenylacetamide. A lead compound 7 represents a new class of mitotic inhibitors that demonstrates potent anti-proliferative activity and selectively induces cancer cell apoptosis while sparing non-transformed lung fibroblast.

Metrics

1 Record Views

Details