Synthesis and biological evaluation of new aza-acyclic nucleosides and their hydrogen complexes from indole

Suzan Alhilal; Mohammad Alhilal; Sobhi M. Gomha; Salama A. Ouf

doi:10.1007/s11164-022-04760-3

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Synthesis and biological evaluation of new aza-acyclic nucleosides and their hydrogen complexes from indole

Journal article

Peer reviewed

Synthesis and biological evaluation of new aza-acyclic nucleosides and their hydrogen complexes from indole

Suzan Alhilal, Mohammad Alhilal, Sobhi M. Gomha and Salama A. Ouf

Research on chemical intermediates, Vol.48(8), pp.3567-3587

01/08/2022

DOI: https://doi.org/10.1007/s11164-022-04760-3

Abstract

Article

Catalysis

Chemistry

Chemistry and Materials Science

Inorganic Chemistry

Physical Chemistry

Three novel aza-acyclic nucleosides and two hydrogen complexes were isolated by flash chromatography after being produced in a reaction between indole and dibenzosulfonyl diethylamine (which had previously been prepared) in the presence of sodium and absolute ethanol as a basic catalyst. Structures of new compounds and complexes were determined by 1D-NMR: 1 H NMR, 13 C NMR, DEPT-135, 2D-NMR: COSY, HMQC, HSQC, HMBC, IR, and MS spectroscopy. The synthesized compounds were evaluated against a wide range of microorganisms, including Gram-positive and Gram-negative bacteria as well as fungal strains. These compounds showed good biological activity.

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Title: Synthesis and biological evaluation of new aza-acyclic nucleosides and their hydrogen complexes from indole
Creators - without role: Suzan Alhilal - Al-Baath University
Mohammad Alhilal - Mardin Artuklu University
Sobhi M. Gomha - Islamic University of Madinah
Salama A. Ouf - Cairo University
Publication Details: Research on chemical intermediates, Vol.48(8), pp.3567-3587
Publisher: Springer Netherlands
Identifiers: 9917096508331
Academic Unit: Islamic University of Al Madinah
Language: English
Resource Type: Journal article