Abstract
Condensation of hydralazine 1 with ethyl oxalate afforded triazinodione 3 or s-triazolo derivative 4, while with alpha-bromo ketones, 1,2-cyclohexanedione and pyridine keto acid it gave the as-triazino derivatives a-a respectively. Reaction of 1 with bromo esters yield the corresponding 3-bromo-alkyl s-triazolophthalazines 9. Condensation of 9a with hydrazine hydrate followed by acetylacetone afforded the pyrazole derivative ii. Cyclization of 1 with acid chlorides or ketones gave the appropriate 3-substitutes s-triazolophthalazines. With chloromalonic acid ester, 1 yielded the triazino-triazolo derivative 18, while with pyridine acetal it gave the his s-triazolophthalazine 19.