Abstract
New glycosyl derived ligand and its complexes, with SnCl4 center dot 5H(2)O (1) and (CH3)(2)SnCl2 (2) were synthesized and characterized by spectroscopic (IR, H-1, C-13, and Sn-119 NMR, UV-vis, ESI-MS) and analytical methods. Interaction studies of 1 and 2 with CT DNA were studied by using various biophysical techniques, which showed high binding affinity of 2 with CT DNA. In vitro cytotoxicity of complexes 1 and 2 were evaluated against different human cancer cell lines of different histological origins by employing SRB Assay. The organotin(IV) complex 2 exhibited remarkable activity against DWD (oral cancer) cell lines with GI(50) values <10 mu g/ml. Complex 2 induced apoptosis of DWD cell line at a very low concentration of 1-4 mu g/mL. (C) 2011 Elsevier B. V. All rights reserved.