Abstract
The synthesis, spectroscopy, and antitumor behavior of organotin(IV) complexes of 2,3-methylenedioxyphenylpropenoic acid are described. The spectroscopic data indicate 1 : 2 and 1 : 1 metal to ligand stoichiometry in case of di- and trioganotin(IV) compounds and hypervalency of Sn(IV) in trigonal bipyramidal and octahedral modes. Mass spectrometric and elemental analysis data support the solid and solution spectroscopic results. The complexes have been evaluated in vitro against crown gall tumor and bio-activity screenings showed in vitro biological potential. The nature of covalent attachments (methyl, ethyl, n-butyl, phenyl, and n-octyl) of Sn(IV) played a decisive role for bioactivity. All the compounds have been studied in solution by NMR (1H, 13C) and also in solid state using FTIR, mass spectrometry, and by X-ray crystallography. The molecular structure of Et2Sn(IV) and Me3Sn(IV) derivatives confirm the behavior of di- and tri-organotin(IV) compounds in solid state. Mono-organotin derivatives are octahedral both in solid and solution.