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Synthesis and discovery of novel hexacyclic cage compounds as inhibitors of acetylcholinesterase
Journal article   Peer reviewed

Synthesis and discovery of novel hexacyclic cage compounds as inhibitors of acetylcholinesterase

Raju Suresh Kumar, Mohamed Ashraf Ali, Hasnah Osman, Rusli Ismail, Tan Soo Choon, Yeong Keng Yoon, Ang Chee Wei, Suresh Pandian and Elumalai Manogaran
Bioorganic & medicinal chemistry letters, Vol.21(13), pp.3997-4000
01/07/2011
DOI: https://doi.org/10.1016/j.bmcl.2011.05.003
PMID: 21621414

Abstract

Chemistry Chemistry, Medicinal Chemistry, Organic Life Sciences & Biomedicine Pharmacology & Pharmacy Physical Sciences Science & Technology
Hexacyclic derivatives share vital pharmacological properties, considered useful in Alzheimer's disease. The aim of this study was synthesis and its evaluation for acetyl cholinesterase inhibitory activity of novel hexacyclic analogues. Compound 4f, showed potent inhibitory activity against acetyl cholinesterase enzyme with IC(50) 0.72 mu mol/L. (C) 2011 Elsevier Ltd. All rights reserved.

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