Abstract
Thiourea analogs 1-20 were synthesized and evaluated for their in vitro beta-glucuronidase inhibitory potential. The compounds 9 (0.86 +/- A 0.01 mu M), 6 (1.24 +/- A 0.01 mu M), 16 (1.64 +/- A 0.02 mu M) and 15 (2.12 +/- A 0.02 mu M) showed potent activity. Other analogs 1-5, 7, 8, 10, 11, 13, 17, 20 showed better activity than standard drug d-saccharic acid 1,4-lactone (47.34 +/- A 0.21 mu M) ranging 4.36-34.4 mu M. All synthetic compounds were characterized by different spectroscopic methods. This study has identified a new class of potent inhibitors beta-glucuronidase.