Abstract
Eleven oxazolone derivatives were synthesized, characterized and screened for phagocyte chemiluminescence, neutrophil chemotaxis, T-cell proliferation, cytokine production from mononuclear cells and cytotoxicity.
Eleven oxazolone derivatives were synthesized and characterized by
1H NMR, EI, IR and UV spectroscopic and CHN analysis. Three compounds, 4-[(
E)-(4-nitrophenyl)methylidene]-2-phenyl-1,3-oxazol-5(4
H)-one (
11), 4-[(
E)-(4-methoxyphenyl)methylidene]-2-methyl-1,3-oxazol-5-one (
12) and 4-[(
E)-(4-nitrophenyl)methylidene]-2-methyl-1,3-oxazol-5(4
H)-one (
13) were screened for phagocyte chemiluminescence, neutrophil chemotaxis, T-cell proliferation, cytokine production from mononuclear cells and cytotoxicity. 4-[(
E)-(4-Nitrophenyl)methylidene]-2-methyl-1,3-oxazol-5(4
H)-one (
13) was found to be the most potent immunomodulator in the series.