Abstract
A series of new 3-arylsulfonylimidazolidine-2,4-diones (
2a
–
2p
) were synthesized by reacting imidazolidine-2,4-diones (
1a
–
1e
) with arylsulfonyl chlorides in the presence of triethyl amine. The imidazolidine-2,4-diones (
1a
–
1e
) were in turn synthesized from the corresponding ketones through Bucherer–Bergs reaction. All the synthesized compounds were characterized on the basis of their spectral (IR,
1
H and
13
C NMR and MS) and microanalytical data. The hypoglycemic activity of the compounds (
2a
–
2p
) was evaluated using alloxanized diabetic rat model. Compound
2a
showed an excellent activity with a reduction in the blood glucose level of −286 ± 7 mg/dL after 5 h of drug administration as compared to −270 ± 8 mg/dL for glipizide. The hypoglycemic activity of compound
2b
(−268 ± 9 mg/dL) was also comparable to the standard drug. However, only moderate activity was observed for compound
2e
.