Abstract
Several derivatives containing the thieno[2,3-d]pyrimidine system were prepared starting from 2-amino-4,5-dihydronaphtho[2,1-b]thiophene-1-carbonitrile(1). In particular, the synthesis and structure characterization of 8,9-dihydronaphtho-[1', 2':4,5]thieno[3,2-e][1,2,4]triazolo[4,3-c]pyrimidine derivatives 13-16 and their isomerization to 8,9-dihydronaphtho[1',2':4,5]thieno[3,2-e][1,2,4]-triazolo[1, 5-c]pyrimidine derivatives 17-20 under different suitable reaction conditions were reported and verified with X-ray analysis. Moreover, compounds 13, 14 and 22 were tested as potential anti-inflammatory agents and derivative 14 showed potent activity in carrageenan test. (c) 2005 Wiley Periodicals, Inc.