Abstract
The synthesis of the multifunctional, hitherto unreported 3-(3-(dimethylamino)acryloyl)-2
H
-naphtho[1,2-
b
][1,4]oxazin-2-one was described and its utility as a versatile building block was demonstrated for the synthesis of some new pyrimidines, pyrazoles, isoxazoles, pyrazolo[
a
]pyrimidines, triazolo[
a
]pyrimidines, pyrido[
d
]pyrimidines, pyrido[d]pyrimidines, piperidines, pyrido[
a
]benzimidazoles, 2
H
-pyran-3carboxamides, benzofurans, naphtho[
b
]furans and pyrazolo[
c
][1, 2, 4]triazines of potential biological activities. The synthesized compounds were characterized by IR,
1
H NMR,
13
C NHR and mass spectral data. Some of the compounds were evaluated for antimicrobial activities.