Abstract
The monobasic unidentate levofloxacin (LEV; (S)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-7H-pyrido[1,2,3-de]-1,4―benzoxazine-6-carboxylic acid) complexes of Ru(III), Pt(IV) and Ir(III) were prepared and well discussed using elemental analyses (CHN), molar conductance, infrared, electronic, effective magnetic moment, 1H-NMR, X-ray powder diffraction, scanning electron microscopy, transmittance electron microscopy and thermogravimetric (TG/DTG) analyses. The IR and electronic spectra of LEV complexes with their assignments were discussed in details which were confirmed that LEV is binding to the metal ions as a neutral unidentate ligand through the nitrogen atom of 4-methylpiperazin-1-yl moiety. The molar ratio of Ru(III) and Ir(III) chelates is 1:3 (Metal: LEV), while Pt(IV) complex has a 1:2M ratio. The general formulas of LEV complexes have been designed as [M(L)n(Cl)x]·yH2O ((1) M=Ru3+, L: LEV, n=3, x=3, y=8; (2) M=Pt4+, L: LEV, n=2, x=4, y=4 and (3) M=Ir3+, L: LEV, n=3, x=3, y=6. The X-ray powder diffraction was used as technique to estimate the particle size of LEV complexes. Thermogravimetric analysis (TG-DTG) was utilized to identify the presence of coordinated, uncoordinated water molecules, mass losses and residual products.
•Preparation of monobasic unidentate levofloxacin complexes of Ru(III), Pt(IV) and Ir(III).•Spectroscopic tools proved that LEV is binding to the metal ions as a neutral unidentate ligand.•The molar ratio of Ru(III) and Ir(III) chelates is 1:3 (Metal: LEV), while Pt(IV) complex has a 1:2M ratio.•The electronic spectra of LEV complexes were scanned in liquid and solid states.•LEV complexes have polycrystalline with nano-sized grains.