Abstract
The synthesis and X-ray structural characterization of Pd(DMPA)Cl-2 complex, where DMPA = N,N-dimethylaminopropylamine, is reported. The complex crystallizes in the space group P2(1)/c, a = 8.8923(4), b = 10.9050(5), c = 11.5006(7) angstrom, (beta = 120.00(18)degrees, V = 948.25(8) angstrom(3), Z = 4. The palladium centre has a typical square-planar geometry with a tetrahedral distortion. Stoichiometry and stability constants of the complexes formed between [Pd(DMPA)(H2O)(2)](2+) and some selected DNA constituents and cytsteine are investigated at 25 degrees C and at constant 0.1 M ionic strength. The concentration distribution diagrams of the various species formed are evaluated. The equilibrium constants for the displacement of coordinated ligands as inosine by cysteine are calculated. The results are expected to contribute to the chemistry of tumour therapy. (C) 2012 Elsevier B.V. All rights reserved.