Abstract
This study is concerned with the synthesis of new 1,2,4-triazoles, 1,3,4-thiadiazoles, and 1,3,4-thiadiazines derivatives. Derivatives
3a–i
were obtained by condensation of 4-amino-3-(4-pyridine)-5-mercapto-1,2,4-triazole
1
with the appropriate aldehyde. Compounds
4a–i
were synthesized in a one pot reaction involving compounds
3a–i
, formaldehyde, and morpholine. Condensation of compound
1
with the appropriate acids or 4-substituted phenacyl bromide gave compounds
6a–d
and
8a–f
respectively. The chemical structures of the newly synthesized derivatives were elucidated using different spectral and elemental methods of analysis. All compounds were evaluated for their anti-inflammatory activity and the most potent derivatives were tested for their analgesic activity using indomethacin as a reference drug. In addition, ulcerogenicity and LD
50
for the most active compounds were evaluated. Moreover, the antibacterial activities of the newly synthesized derivatives were investigated.