Abstract
We have synthesized new series of bisindole analogs (
-
), characterized by
HNMR and HR-EI-MS and evaluated for their anti-leishmanial potential. All compounds showed outstanding inhibitory potential with IC
values ranging from 0.7 ± 0.01 to 13.30 ± 0.50 µM respectively when compared with standard pentamidine with IC
value of 7.20 ± 0.20 µM. All analogs showed greater potential than standard except
,
and
when compared with standard. Structure activity relationship has been also established for all compounds. Molecular docking studies were carried out to understand the binding interaction of active molecules.