Abstract
A set of 1,2,3-triazole incorporated quinolone antibiotic conjugates 10–15, 17–19 were synthesized via microwave assisted click chemistry technique. Some of the aryl-substituted conjugates 17–19 show promising antibacterial properties against the tested Gram-positive (S. aureus and S. pyogenes) and Gram-negative bacteria (S. typhi) with potency higher than that of the parent antibiotics 1–3. 2D-QSAR modeling supports the observed biological properties.
[Display omitted]
•Quinolone-triazole conjugates were synthesized.•Some of the synthesized conjugates revealed promising antibacterial properties.•Statistically significant 2D-QSAR models support the biological properties.