Abstract
Benzimidazole derivatives 1-20 were synthesized and evaluated for antiglycation and antioxidant potentials. Among the series some analogs showed antiglycating potential ranging in between 182.30 +/- 1.20 and 473.51 +/- 2.17 when compared with standard rutin (IC50 value 295.09 +/- 1.04 mu M) and for antioxidant potential ranging between 22.42 +/- 0.26 and 82.30 +/- 1.33 when compare with standard Propyl gallate (IC50 value 29.20 +/- 1.25). Compound 2, 6, 10 and 19 showed potent antioxidant and antiglycation inhibitory potentials. Compounds 7, 11, 13, 15 and 20 showed moderate antiglycating potential with IC50 values 473.51 +/- 2.17, 325.20 +/- 1.70, 440.0 +/- 3.60, 370.60 +/- 2.80 and 415.20 +/- 3.20 mu M, and these compounds also showed excellent antioxidant potential with IC50 values 73.51 +/- 1.17, 45.63 +/- 0.92, 82.30 +/- 1.33, 75.41 +/- 1.51, 40.60 +/- 0.80 and 64.92 +/- 1.41 mu M respectively. The remaining compounds 1, 3, 4, 5, 8, 9, 12, 14, 16, 17and 18 were found inactive. (C) 2018 The Authors. Production and hosting by Elsevier B.V.