Abstract
Two series of fused tricyclic sultams (carboxylates, 3a, b and 5a, f, g and anilides 5b-e) were synthesized from saccharin and their chemical structures were confirmed by spectroscopic tools. Then, their antibacterial activities and MIC were evaluated against two strains of gram positive and gram-negative bacteria. The MIC values of the tested compounds are in the of range 8–33 μg/ml. In addition, their DNA cleavage ability, binding affinity and their anticancer activities against hepatic cancer cell were tested. And their antioxidant activities were also measured. Four carboxylate derivatives (3a, 5a, 5f and 5g) and one anilide (5d) of the tested compounds proved to be the highest activity all over the study.
•Two series of fused tricyclic sultams have been synthesized from saccharin in excellent yield.•Four derivatives of the tested compounds showed very good antimicrobial activity.•Three derivatives showed significant antioxidant activity compared to the reference compound.•One of the tested compounds showed a significant anticancer activity against hepatic cancer cell.