Abstract
In the present study, a series of 2/3-bromo-N'-(substituted benzylidene/3-phenylallylidene) benzohydrazides was synthesized and evaluated in vitro for its antimicrobial and anticancer potentials. The results of antimicrobial and anticancer study indicated that compounds 3, 15 and 18 (pMIC(am) = 1.62 mu M/ml) were found to be most potent antimicrobial agents and compound 4 (IC50 = 1.88 +/- 0.03 mu M) was found to be the most potent anticancer agent. The results of QSAR analysis indicated the importance of topological parameters, Balaban index (J) and valence first and second order molecular connectivity indices ((1)chi(v) and (2)chi(v)) in describing antimicrobial activity of the synthesized benzohydrazides. (c) 2014 Production and hosting by Elsevier B.V. on behalf of King Saud University.