Abstract
A series of naphthalene ring containing 2,4,5-trisubstituted imidazole derivatives (2a-2l) were synthesized using one-pot multicomponent reaction. The reactions were carried out using naphthaldehyde and substituted benzil in the presence of ammonium acetate in acetic acid media. All newly synthesized imidazole derivatives were characterized by FT-IR, 1H NMR, 13C NMR and mass spectral analysis. Newly synthesized imidazole derivatives were screened for their in-vitro antioxidant activity by DPPH free radical scavenging assay method and alpha-amylase inhibition activity by DNS method. All the compounds showed excellent alpha-amylase activity at 10, 50 and 100 mu g/mL and compounds 2d, 2g, 2k exhibited good antioxidant activity.Graphic abstractA series of naphthalene ring containing 2,4,5-trisubstituted imidazole derivatives (2a-2l) were synthesized through one-pot multicomponent reaction using naphthaldehyde, substituted benzil and ammonium acetate in acetic acid medium with good yield. The structure of all compounds were confirmed by spectroscopic methods and evaluated for their in vitro alpha-amylase inhibition and antioxidant activity.