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Synthesis, biological evaluation and radiolabelling by F-18-fluoroarylation of a dopamine D-3-selective ligand as prospective imaging probe for PET
Journal article   Peer reviewed

Synthesis, biological evaluation and radiolabelling by F-18-fluoroarylation of a dopamine D-3-selective ligand as prospective imaging probe for PET

S. B. Hoefling, S. Maschauer, H. Huebner, P. Gmeiner, H. -J. Wester, O. Prante and M. R. Heinrich
Bioorganic & medicinal chemistry letters, Vol.20(23), pp.6933-6937
01/12/2010
DOI: https://doi.org/10.1016/j.bmcl.2010.09.142
PMID: 21030255

Abstract

Chemistry Chemistry, Medicinal Chemistry, Organic Life Sciences & Biomedicine Pharmacology & Pharmacy Physical Sciences Science & Technology
Radical F-18-fluoroarylation with fluorine-18-labelled arenediazonium chlorides has been successfully applied to the radiochemical synthesis of the dopamine D-3-selective ligand SH 317 ([F-18]8). SH 317 has been evaluated as a new PET ligand candidate by in vivo experiments. (C) 2010 Elsevier Ltd. All rights reserved.

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