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Synthesis, characterization and RHF/ab initio simulations of 2-amino-1,3,4-thiadiazole and its annulated ring junction pyrimidine derivatives
Journal article   Open access  Peer reviewed

Synthesis, characterization and RHF/ab initio simulations of 2-amino-1,3,4-thiadiazole and its annulated ring junction pyrimidine derivatives

Wafaa S. Hamama, Moustafa A. Gouda, Mamdouh S. Soliman, Marwa H. Badr and Hanafi H. Zoorob
Journal of advanced research, Vol.4(1), pp.69-73
01/01/2013
DOI: https://doi.org/10.1016/j.jare.2012.01.005
PMCID: PMC4195460
PMID: 25685403

Abstract

Multidisciplinary Sciences Science & Technology Science & Technology - Other Topics
Michael addition reaction of the 2-amino-1,3,4-thiadiazole to chalcone as biselectrophile afforded 5,7-diphenyl-6-[ 1,3-diphenylpropan-1-on-3-yl][1,3,4] thiadiazolo[3,2-a] pyrimidine (3) instead of 5,7-diphenyl-5H-[1,3,4] thiadiazolo[3,2-a] pyrimidine (5) via further Michael addition at C-5 in pyrimidine moiety. The structure 3 was established through the aspect of ab initio calculations, elemental analysis and spectral data. (C) 2012 Cairo University. Production and hosting by Elsevier B.V. All rights reserved.
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https://doi.org/10.1016/j.jare.2012.01.005View
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