Abstract
In the present study steroidal derivatives, 3 beta-[5'-mercapto-1',3',4'-oxadiazole-2-yl]methoxy cholest-5-ene 2, 3 beta-[2',5'-dimethylpyrrole-1-yl]aminocarbonylmethoxycholest-5-ene 3 and 3 beta-[3',5'-dimethyl pyrazole-1-yl]carbonylmethoxycholest-5-ene 4 have been synthesized from cholest-5-en-3 beta-O-acetyl hydrazide 1 using CS2/KOH, acetonyl acetone and acetyl acetone, respectively as reagents and are characterized by IR, H-1 NMR, C-13 NMR, MS and elemental analysis. Compounds 2-4 were also evaluated for anticancer activity against human leukemia cell line (HL-60) by MTT assay and compound 4 displayed the promising behavior by showing better anticancer activity. (C) 2012 Production and hosting by Elsevier B.V. on behalf of King Saud University.