Abstract
A new modified chitosan derivative (N-acetyl,N'-chitosanacetohydrazide, ACsAH) and its cobalt(II), nickel(II), manganese(II), and copper(II) complexes were successfully prepared. Their structures were proven using elemental analysis, FTIR,
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H-NMR and electronic spectroscopy, magnetic moment, and molar conductance. An octahedral stereochemistry for all the synthesized ACsAH-metal complexes was proposed. Their activity against the tested microbes can be arranged as follows: ACsAH-Mn(II) complex > ACsAH-Co(II) complex > ACsAH-Ni(II) complex > ACsAH-Cu(II) complex > ACsAH > chitosan. The ACsAH-Mn(II) complex exhibited a greater potency in inhibition of the growth of some of the tested microbes than that of the used standard drugs.