Abstract
[Cu
2
L(phen)(H
2
O)
3
(ClO
4
)](ClO
4
)
3
{phen = 1,10-phenanthroline, L = 4-((bis(pyridine2-ylmethyl)amino)methyl)-N,N-bis(pyridin-2-ylmethyl)aniline} was prepared and characterized by physical chemical techniques. The X-ray single-crystal structure analysis shows an unsymmetrical dinuclear species. The interaction of the complex with calfthymus DNA (CT-DNA) was studied by various spectroscopic and viscosity measurements, which indicate that the complex can interact with CT-DNA through intercalation. In the presence of H
2
O
2
, the complex can cleave pBR322 DNA more efficiently and hydroxyl radicals (HO
.
) may serve as the major cleavage active species. Interactions of the compound with bovine serum albumin (BSA) were also investigated using UV−Vis and fluorescence spectroscopic methods. The results show that the complex quenches the intrinsic fluorescence of BSA by a static quenching mechanism.
The X-ray single-crystal structure analysis shows that the complex is an unsymmetrical dinuclear species.