Abstract
Compounds
1
–
30
showed varying degree of
α
-glucosidase inhibition with IC
50
values ranging between 187 and 420
μ
M. Compounds
1
,
2
,
3
,
6
,
8
,
12
, and
4
(IC
50
= 187.7 ± 3.05, 203.4 ± 4.0, 240.7 ± 1.9, 252.9 ± 3.9, 285.2 ± 6.3, 399.07 ± 1.2, and 420.36 ± 5.6 μM, respectively) were found to be more active than standard acarbose (IC
50
= 906 ± 6.3 μM). The synthetic compounds were also tested for urease inhibition. Compounds
5
(IC
50
= 19.6 ± 1.0 μM) and
1
(IC
50
= 21.6 ± 0.6 μM) showed better activity than standard drug thiourea (IC
50
= 21.8 ± 1.6 μM). The crystal structures of compounds
15
and
16
are also reported.
Graphical Abstract
Compounds 1−30 synthesized and evaulated for Alpha-glucosidase as well as Ureas inhibition. The crystal structures of compounds
15
and
16
are also reported