Abstract
Palladium(II) complexes with triphenylphosphine (PPh
3) and thioamides of the general formulae, [Pd(L)
2(PPh
3)
2]Cl
2 and [Pd(L)
2(PPh
3)
2] have been prepared and characterized by elemental analysis, IR and NMR (
1H,
13C and
31P) methods, and two of them (
trans-[Pd(PPh
3)
2(Dmtu)
2]Cl
2·(H
2O)(CH
3OH)
0.5 (
1) and
trans-[Pd(PPh
3)
2(Mpy)
2] (
2)) by X-ray crystallography; where L
=
thiourea (Tu), methylthiourea (Metu),
N,
N′-dimethylthiourea (Dmtu), tetramethylthiourea (Tmtu), 2-mercaptopyridine (Mpy), 2-mercaptopyrimidine (Mpm) and thionicotinamide (Tna). The crystal structures of the complexes show that (
1) has ionic character consisting of [Pd(PPh
3)
2(Dmtu)
2]
+2 cations and uncoordinated Cl
− ions, while (
2) is a neutral complex with Mpy behaving as anionic thiolate ligand. The complexes were screened for antibacterial effects, brine shrimps lethality bioassay and antitumor activity.
Palladium(II) complexes with triphenylphosphine (PPh
3) and thioamides of the general formulae, [Pd(L)
2(PPh
3)
2]Cl
2 and [Pd(L)
2(PPh
3)
2] have been prepared and characterized by elemental analysis, IR and NMR (
1H,
13C and
31P) methods, and two of them (
trans-[Pd(PPh
3)
2(Dmtu)
2]Cl
2·(H
2O)(CH
3OH)
0.5 (
1) and
trans-[Pd(PPh
3)
2(Mpy)
2] (
2)) by X-ray crystallography; where L
=
thiourea (Tu), methylthiourea (Metu),
N,
N′-dimethylthiourea (Dmtu), tetramethylthiourea (Tmtu), 2-mercaptopyridine (Mpy), 2-mercaptopyrimidine (Mpm) and thionicotinamide (Tna). The spectral data of the complexes are consistent with the sulfur coordination of thioamides to palladium(II). The crystal structures of the complexes show that (
1) has ionic character consisting of [Pd(PPh
3)
2(Dmtu)
2]
+2 cations and uncoordinated Cl
− ions, while (
2) is a neutral complex with Mpy behaving as anionic thiolate ligand. The coordination environment around palladium in (
2) is nearly regular square-planar, while in (
1) the
trans angles show significant distortions from 180°. The complexes were screened for antibacterial effects, brine shrimps lethality bioassay and antitumor activity. These complexes showed significant activities in most of the cases against the tested bacteria as compared to that of a standard drug. Their antitumor activity against prostate cancer cells (PC3) is comparable with doxorubicin, together with no cytotoxic effects in brine shrimps lethality bioassay study.