Abstract
A series of 2-amino-4
-benzo[
]chromene and 2,7-diamino-4
-benzo[
]chromene derivatives were prepared as potential cytotoxic agents. The structures of the synthesised compounds were established on the basis of spectral data. The in-vitro cytotoxic activity of the synthesised compounds against the cell lines MCF-7, HCT-116 and HepG-2 was investigated in comparison with vinblastine and colchicine, using an MTT colorimetric assay. The structure-activity relationship of 4
-benzo[
]chromenes with modification at the 3-, 4- and 7-positions was explored. The results of the anti-tumour evaluation revealed that compounds
and
,
inhibited the growth of MCF-7 in comparison with vinblastine and colchicine, while
,
inhibited the growth of HCT-116 in comparison with colchicine. In addition, compounds
and
,
inhibited the growth of HepG-2 in comparison with vinblastine and colchicine, respectively.