Abstract
Biscoumarin analogs 1-18 have been synthesized, characterized by EI-MS and H-1 NMR and evaluated for a-glucosidase inhibitory potential. All compounds showed variety of alpha-glucosidase inhibitory potential ranging in between 13.5 +/- 0.39 and 104.62 +/- 0.3 mu M when compared with standard acarbose having IC50 value 774.5 +/- 1.94 mu M. The binding interactions of the most active analogs were confirmed through molecular docking. The compounds showed very good interactions with enzyme. All synthesized compounds 1-18 are new. Our synthesized compounds can further be studied to developed lead compounds. (C) 2015 Elsevier Inc. All rights reserved.