Abstract
A series of new fluorinated quinolines were synthesized and screened for their anti-inflammatory activity. The benzimidazole derivative 3a was found to be most potent among the series.
•New fluorinated quinolines were synthesized.•Screening of anti-inflammatory activity was performed for compounds 2–12.•Molecular modeling study was performed for compounds (1–12).
Several new fluorinated quinoline derivatives were synthesized and tested for their anti-inflammatory and ulcerogenic effect. A docking study on the COX-2 binding pocket was carried out for the target compounds to rationalize the possible selectivity of them against COX-2 enzyme. The most active compounds (3, 2, 7 and 11) were found to be superior to celecoxib as they were devoid of any ulcerogenic activity. Compound 3a demonstrated the highest anti-inflammatory activity as well as the best binding profiles into the COX-2 binding site. Moreover, compounds 3–12 were screened for antibacterial activity and none of them showed noteworthy activity.