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Synthesis of 2-Aminoindoles through Gold-Catalyzed C-H Annulations of Sulfilimines with N-Arylynamides
Journal article   Peer reviewed

Synthesis of 2-Aminoindoles through Gold-Catalyzed C-H Annulations of Sulfilimines with N-Arylynamides

Xianhai Tian, Lina Song, Matthias Rudolph, Frank Rominger and A. Stephen K. Hashmi
Organic letters, Vol.21(11), pp.4327-4330
07/06/2019
PMID: 31117714

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
A new gold-catalyzed C-H annulation of sulfilimines with N-phenylynamides is presented. As key intermediates of this operationally simple reaction, the in situ generated a-imino gold carbenes insert into the ortho C-H bonds of the phenyl groups to afford 2-aminoindoles bearing a variety of substitution patterns in high selectivities. This reaction offers a facile approach to biologically important 2-aminoindoles by using inexpensive and readily available starting materials.

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