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Synthesis of 2-fluorotetralones by oxidative radical cyclization of α-fluoroacetophenones and olefins
Journal article   Peer reviewed

Synthesis of 2-fluorotetralones by oxidative radical cyclization of α-fluoroacetophenones and olefins

Markus R. Heinrich
Tetrahedron letters, Vol.48(22), pp.3895-3900
28/05/2007
DOI: https://doi.org/10.1016/j.tetlet.2007.03.128

Abstract

2-Fluorotetralones Manganese(III) acetate Radical cyclization α-Fluoroacetophenones
The oxidative radical cyclization of α-fluoroacetophenones in the presence of olefins offers an efficient access to 2-fluorotetralones. Fluorinated starting materials can be prepared from α-bromoacetophenones. The reaction was optimized with respect to a future application in the synthesis of 18-fluorine labeled compounds, where reaction times are a critical aspect.

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