Abstract
Condensation of thiourea with 3-bromo-3-aryl propionates yielded 2-amino-4-aryl thiazole-5-acetates (3a-c). The compounds (3a-c) were hydrolyzed to thiazole-5-acetic acids (3d-f). The esters (3a-c) and acids (3d-f) were subjected to acylation with acetic anhydride and succinic anhydride to give the title compounds (4a-d and 5a-f). Anti-inflammatory and analgesic activities of some compounds have been evaluated.