Abstract
2,4,6-Trichlorophenyl hydrazones 1-35 were synthesized and their in vitro antiglycation potential was evaluated. Compounds 14 (IC50 = 27.2 +/- 0.00 mu M), and 18 (IC50 = 55.7 +/- 0.00 mu M) showed an excellent activity against glycation of protein, better than the standard (rutin, IC50 = 70 +/- 0.50 mu M). This study thus identified a novel series of antiglycation agents. A structure-activity relationship has been studied, and all the compounds were characterized by spectroscopic techniques.