Abstract
A series of fused and non fused 1,2,4-triazoles with (2,4-dichlorophenoxy) moiety are prepared utilizing 3-((2,4-dichlorophenoxy)methyl)-4-amino-4
H-1,2,4-triazole-5-thiol (
3). The latter on reaction with carboxylic acids, ethylchloroformate, ethylcyanoacetate and sodium nitrite gives five membered fused triazole derivatives
4a–
d,
5,
6,
7 and
10, respectively. The six membered heterocycles
11,
12 and
14 are prepared by cyclization of compound
3 with phenacyl bromide, chloroacetic acid and α-bromoketone respectively. Most of the newly synthesized compounds were screened for their anti-inflammatory and molluscicidal activities. The compounds
4b,
4d,
11 and
14 showed potent anti-inflammatory activities in dose dependent manner while compounds
3,
4b,
8 and
10 exhibited promising molluscicidal activities.
[Display omitted]