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Synthesis of 3′-Amino and 5′-Amino Hydantoin 2′-Deoxynucleosides
Journal article

Synthesis of 3′-Amino and 5′-Amino Hydantoin 2′-Deoxynucleosides

Ahmed A. El-Barbary, Ahmed I. Khodair, Erik B. Pedersen, Claus Nielsen and A. A. El-Barbary
Nucleosides & nucleotides, Vol.13(1-3), pp.707-717
01/03/1994
DOI: https://doi.org/10.1080/15257779408013274

Abstract

3′-Amino and 5′-amino derivatives of hydantoin 2′-deoxynucleosides have been prepared from the corresponding 3′-phthalimido and 5′-azido nucleosides, respectively, which in turn were prepared by condensation of appropriate sugars with 5-benzylidenehydantoin. The amino nucleosides were tested for their potential activity against HIV and HSV.

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