Abstract
A series of 1,2,4-thiadiazoles 3a-e were prepared by oxidation of arylthioureas with hydrogen peroxide and condensing with phenylisothiocynate. The identity of the compounds was confirmed on the basis of their elemental analysis and spectral data. The compound with para-chloro substitution 3c showed maximal activity in MES test and blocked strychnine seizures to some extent whereas other compounds of the series were less active.