Synthesis of 4-alkoxy-4-methyl- and 4-alkoxy-4-fluoromethyl-1,3-benzoxazinones

Hamad Z Alkhathlan

doi:10.1016/j.tet.2003.08.044

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Synthesis of 4-alkoxy-4-methyl- and 4-alkoxy-4-fluoromethyl-1,3-benzoxazinones

Journal article

Peer reviewed

Synthesis of 4-alkoxy-4-methyl- and 4-alkoxy-4-fluoromethyl-1,3-benzoxazinones

Hamad Z Alkhathlan

Tetrahedron, Vol.59(41), pp.8163-8170

06/10/2003

DOI: https://doi.org/10.1016/j.tet.2003.08.044

Abstract

1,3-benzoxazinones

2-hydroxyacetophenone

hydrazones

triphosgene

Cyclization of 2-hydroxyacetophenone hydrazones with triphosgene resulted in the formation of 4-methylene-1,3-benzoxazinones. These compounds were converted to 4-alkoxy-4-methyl-1,3-benzoxazinones and 4-fluoromethyl-4-methoxy-1,3-benzoxazinones upon treatment with alcohols under refluxing conditions and F-TEDA-BF 4 in acetonitrile and methanol, respectively. Graphic

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Title: Synthesis of 4-alkoxy-4-methyl- and 4-alkoxy-4-fluoromethyl-1,3-benzoxazinones
Creators - without role: Hamad Z Alkhathlan - King Saud University
Publication Details: Tetrahedron, Vol.59(41), pp.8163-8170
Publisher: Elsevier Ltd
Identifiers: 9949340008331
Academic Unit: King Saud University
Language: English
Resource Type: Journal article