Abstract
Many substituted acridin-2-yl(phenyl) methanones have been successfully prepared in good yields by reacting functionally substituted aryl halides with many internal acetylenes in presence of a palladium catalyst Pd(dba)2. The end product of this reaction has also been synthesized via reaction of cis- and trans3-(2-chlo ro-6-methoxyquinolin-3-yl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-l-one palladium complexes towards acetylene in an aqueous medium. This reaction was believed to proceed via region -selective arylpalladation of the acetylene and subsequent nucleophilic displacement of the palladium, which further produced vinylpalladium intermediates. The intermediates and the final products have been tested for broad-spectrum antibacterial and antibiofilm activities.