Abstract
Benzophenonehydrazone Schiff bases 1-25 were synthesized and their in vitro antiglycation potential has been studied. Out of twenty-five compounds, thirteen showed varying degrees of antiglycation activity with IC50 values ranging between 25.7 - 305 mu M, if compared with the standard rutin (IC50 = 70.5 +/- 0.50 mu M). Compounds 21 (2,3-dihydroxybenzaldehyde N-(diphenylmethylene)hydrazine) IC50 = 25.7 +/- 0.003 mu M, 14 (diphenylmethanone N-[1-(2,4-dihydroxy-5-nitrophenyl)ethylidene]hydrazine) IC50 = 36.6 +/- 0.004 mu M, 6 (3,4-dihydroxybenzaldehyde N-( diphenylmethylene)hydrazine) IC50 = 49.5 +/- 0.001 mu M, 13 (diphenylmethanone N-[1-(2,5-dihydroxyphenyl)ethylidene]hydrazine) IC50 = 52.6 +/- 0.023 mu M, and 15 (diphenylmethanone N-[1-(3,4-dihydroxyphenyl)ethylidene]hydrazine) IC50 = 57 +/- 0.002 mu M, showed showed much better antiglycation potential superior to the standard rutin. The compounds 7 (2,5-dihydroxybenzaldehyde N-(diphenylmethylene)hydrazine) IC50 = 66 +/- 0.002 mu M, and 25 (diphenylmethanone N-[1-(2,5-dihydroxyphenyl)propylidene]hydrazine) IC50 = 67.9 +/- 0.001 mu M showed compareably good antiglycation activity to standard rutin. All compounds were characterized by spectroscopic techniques and gave satisfactory elemental analysis.