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Synthesis of Functionalized Pyrano[3,2-c]pyridines and Their Transformations to 4-Hydroxy-3[(1E)-N-hydroxyalkanimidoyl]pyridones
Journal article   Peer reviewed

Synthesis of Functionalized Pyrano[3,2-c]pyridines and Their Transformations to 4-Hydroxy-3[(1E)-N-hydroxyalkanimidoyl]pyridones

Farag A. El-Essawy, Ahmed F. Khattab, Magdy A. Zahran and Sherif H. Gomaa
Synthetic communications, Vol.37(18), pp.3225-3237
01/09/2007
DOI: https://doi.org/10.1080/00397910701547995

Abstract

4-hydroxy-2-pyridones ethyl malonates pyrano[3,2-c]pyridines
Reaction of 4-hydroxy-6-methyl-2(1H)-pyridones 1a and 4-hydroxy-1,6-dimethyl-2(1H)-pyridones 1b with diethyl malonates 2a-e leads to the formation of pyrano[3,2-c]pyridines 4a-j. Degradation of 4a-i affords the corresponding ketones 6a-i. Condensation of ketones 6a-i with hydroxyl amine or phenyl hydrazine hydrochloride is described.

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