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Synthesis of New 4-Oxo-thiazolidine-5-ylidenes of Antitumor and Antioxidant Activities
Journal article   Peer reviewed

Synthesis of New 4-Oxo-thiazolidine-5-ylidenes of Antitumor and Antioxidant Activities

Ashraf A. Aly, Alan B. Brown, Mohamed Abdel-Aziz, Gamal El-Din A. A. Abuo-Rahma, Mohamed F. Radwan, Mohamed Ramadan and Amira M. Gamal-Eldeen
Journal of heterocyclic chemistry, Vol.47(3), pp.547-554
05/2010
DOI: https://doi.org/10.1002/jhet.290

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
Reaction of diacyl thiocarbohydrazides with dimethyl but-2-ynedioate in refluxing ethanol led to oxa-thiazolidine-5-ylidene-acetates in good yields. Reaction of the newly prepared N-(2-(propan-2-ylidene) hydrazine-carbonothioyl)arylhydrazides with dimethyl but-2-ynedioate gave the corresponding (Z)-methyl-2-arylhydrazide-4-oxo-3-(propan-2-ylideneamino)thiazolidine-5-ylidene)-acetates. The mechanism is discussed. Antitumor and antioxidant activities have been also investigated.

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