Abstract
Starting from 6-(2,6-dibromo-4,7-dimethoxybenzofuran-5-yl)-2-hydrazinyl-4-(4-methoxyphenyl) nicotinonitrile 5, novel heterocyclic derivatives of benzofuran were synthesized 6-18. Biological evaluation in vitro revealed that compounds 15, 6, 10 and 18 exhibited a wide range of antibacterial activity against gram positive and gram negative bacteria.