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Synthesis of Novel 2,5-Disubstituted-1,3,4-thiadiazoles Clubbed 1,2,4-Triazole, 1,3,4-Thiadiazole, 1,3,4-Oxadiazole and/or Schiff Base as Potential Antimicrobial and Antiproliferative Agents
Journal article   Open access  Peer reviewed

Synthesis of Novel 2,5-Disubstituted-1,3,4-thiadiazoles Clubbed 1,2,4-Triazole, 1,3,4-Thiadiazole, 1,3,4-Oxadiazole and/or Schiff Base as Potential Antimicrobial and Antiproliferative Agents

Nadjet Rezki, Amjad M Al-Yahyawi, Sanaa K Bardaweel, Fawzia F Al-Blewi and Mohamed R Aouad
Molecules (Basel, Switzerland), Vol.20(9), pp.16048-16067
01/09/2015
DOI: https://doi.org/10.3390/molecules200916048
PMCID: PMC6331880
PMID: 26364633

Abstract

Anti-Infective Agents - chemical synthesis Anti-Infective Agents - chemistry Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Oxadiazoles - chemistry Proton Magnetic Resonance Spectroscopy Schiff Bases - chemistry Thiadiazoles - chemistry Triazoles - chemistry
In the present study, a new series of 2,5-disubstituted-1,3,4-thiadiazole tethered 1,2,4-triazole, 1,3,4-thiadiazole, 1,3,4-oxadiazole and Schiff base derivatives were synthesized and characterized by IR, ¹H-NMR, (13)C-NMR, MS and elemental analyses. All compounds were screened for their antibacterial, antifungal and antiproliferative activity. Some of the synthesized derivatives have displayed promising biological activity.
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https://doi.org/10.3390/molecules200916048View
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