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Synthesis of Novel Substituted Pyridines from 1-(3-Aminophenyl)-3-(1H-indol-3-yl)prop-2-en-1-one and Their Anticancer Activity
Journal article   Peer reviewed

Synthesis of Novel Substituted Pyridines from 1-(3-Aminophenyl)-3-(1H-indol-3-yl)prop-2-en-1-one and Their Anticancer Activity

S. F. Mohamed, H. M. Hosni, A. E. Amr and M. M. Abdalla
Russian journal of general chemistry, Vol.86(3), pp.672-680
01/03/2016
DOI: https://doi.org/10.1134/S1070363216030269

Abstract

Chemistry Chemistry, Multidisciplinary Physical Sciences Science & Technology
A series of novel substituted pyridine derivatives have been synthesized via the reaction of 3-indole carboxaldehyde with 3-aminoacetophenone. The products structures have been elucidated from elemental analysis as well as IR, H-1 NMR, C-13 NMR, and MS spectroscopy data. All the synthesized compounds have shown anticancer activity against HEPG2 and MCF-7 in vitro; some of them have exhibited the in vivo activity.

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