Synthesis of Potential Antiviral Agents for SARS-CoV-2 Using Molecular Hybridization Approach

Kailey A. Wyman; Adel S. Girgis; Pragnakiran S. Surapaneni; Jade M. Moore; Noura M. Abo Shama; Sara H. Mahmoud; Ahmed Mostafa; Reham F. Barghash; Zou Juan; Radha D. Dobaria; Ahmad J. Almalki; Tarek S. Ibrahim; Siva S. Panda

doi:10.3390/molecules27185923

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Synthesis of Potential Antiviral Agents for SARS-CoV-2 Using Molecular Hybridization Approach

Journal article

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Synthesis of Potential Antiviral Agents for SARS-CoV-2 Using Molecular Hybridization Approach

Kailey A. Wyman, Adel S. Girgis, Pragnakiran S. Surapaneni, Jade M. Moore, Noura M. Abo Shama, Sara H. Mahmoud, Ahmed Mostafa, Reham F. Barghash, Zou Juan, Radha D. Dobaria, …

Molecules (Basel, Switzerland), Vol.27(18), p.5923

12/09/2022

DOI: https://doi.org/10.3390/molecules27185923

PMID: 36144662

Abstract

Biochemistry & Molecular Biology

Chemistry

Chemistry, Multidisciplinary

Life Sciences & Biomedicine

Physical Sciences

Science & Technology

We synthesized a set of small molecules using a molecular hybridization approach with good yields. The antiviral properties of the synthesized conjugates against the SAR-CoV-2 virus were investigated and their cytotoxicity was also determined. Among all the synthesized conjugates, compound 9f showed potential against SARS-CoV-2 and low cytotoxicity. The conjugates' selectivity indexes (SIs) were determined to correlate the antiviral properties and cytotoxicity. The observed biological data were further validated using computational studies.

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Title: Synthesis of Potential Antiviral Agents for SARS-CoV-2 Using Molecular Hybridization Approach
Creators - without role: Kailey A. Wyman - Augusta University
Adel S. Girgis - National Research Centre
Pragnakiran S. Surapaneni - Augusta University
Jade M. Moore - Augusta University
Noura M. Abo Shama - National Research Centre
Sara H. Mahmoud - National Research Centre
Ahmed Mostafa - National Research Centre
Reham F. Barghash - National Research Centre
Zou Juan - Augusta University
Radha D. Dobaria - Augusta University
Ahmad J. Almalki - King Abdulaziz University
Tarek S. Ibrahim - King Abdulaziz University
Siva S. Panda - Augusta University
Publication Details: Molecules (Basel, Switzerland), Vol.27(18), p.5923
Publisher: Mdpi
Number of pages: 15
Grant note: RG-34-166-43 / Deanship of Scientific Research (DSR) at King Abdulaziz University (KAU), Jeddah, Saudi Arabia
Identifiers: 9939237608331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article