Abstract
A series of 2-thioxoquinazolinone derivatives 2a-d have been synthesized via condensation of the anthranilic acid derivatives with aryl isothiocyanate in the presence of absolute ethanol using ultrasound irradiation method. The substituted-4-oxoquinazolin-2-yl-thioethylacetate derivatives 3a-d were prepared by S-alkylation of quinazolin-2-thione derivatives 2a-d with ethyl chloro acetate followed by hydrazine hydrate offered the hydrazide derivatives 4a-d. The structures of the synthesized compounds were mainly confirmed on the basis of spectroscopic methods. The synthesized compounds 2a-d, 3a-d, 4a and 4c, d were screened for antibacterial and antifungal activities.