Abstract
Some new fluorinated 3-substituted amino-1,2,4-triazino[5,6-b]indoles (2-9) and 3-substituted amino-imidazo[3,2-b][1,2,4]triazino[5,6-b]indoles (11-14) have been obtained from the reactions of 3-amino-5H-8-fluoro-1,2,4-triazine (1) with alkyl/acyl compounds, and/or the treatment of 3-aminoimidazo[3,2-b][1,2,4]triazino[5,6-b]indole (10) with the various reagents under the various conditions. Structures of the new compounds were established from elemental analyses and spectral measurements. The fluorinated compounds were evaluated for their anti-inflammatory properties and the compounds 9>3>12>5 exhibited a high activity.
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