Abstract
A series of N-phenacylindolylcarboxylic acids (3-11) as inhibitors of cyclooxygenase-2 (COX-2) enzyme has been synthesized. The compounds 3-11 were prepared by reacting indole intermediates (1a-1c) with different phenacyl bromides (2a-2c). The structures of 3-11 were confirmed on the basis of their spectral data and the elemental analysis. The COX-2 inhibitory assay and the computational molecular property evaluation have revealed compound 7, which demonstrated better potency and percentage of the absorption than standard drug, celecoxib.